January 3, 2017
The Idaho Veterans Research & Education Foundation (IVREF), a nonprofit entity affiliated with the VA Medical Center in Boise, Idaho, announces Post-doctoral Research positions for an NIH funded Center of Excellence in Emerging & Reemerging Infectious Diseases. Candidates will have a recent PhD (<5 years) in microbiology, immunology, cell biology, or related discipline and 0-2 years of post-doctoral experience. Excellent English communication skills and evidence of scientific accomplishments are required. Ongoing projects include:
Molecular and Cellular Mechanisms of Naturally-acquired Immunity to Streptococcus pyogenes exotoxins. Exotoxins mediate necrotizing S. pyogenes infections and antibiotics that prevent toxin production provide superior protection. Given rising antibiotic resistance, we seek novel immune-based therapeutics for these life-threatening infections. A strong background and prior experience in molecular and cellular biology techniques including multi-color flow cytometry/cell sorting, RNA isolation/cloning and animal models of infection is required. Expertise in display methods (phage, yeast, mRNA, etc), B-cell immunology and immortalization and host/pathogen interactions is preferred.
Mechanisms of Antibiotic-induced Toxin Production in Methicillin-resistant Staphylococcus aureus (MRSA). We have shown that some antibiotics increase exotoxin protein production in S. aureus, thereby potentially exacerbating clinical disease. We seek to define regulatory/signaling pathways involved to identify novel therapeutic targets to improve treatment of severe MRSA infection. A strong background in molecular biology, microbial physiology and/or microbial genetics is required. Experience in next-gen transcriptome sequencing and animal models of infection is preferred.
Mechanisms of the Leukemoid Reaction (LR) in Life-threatening Clostridial infections. LR development is a significant predictor of fatal outcome in these infections; however, the underlying mechanisms and the role of the LR in pathogenesis are not understood. Investigations may reveal novel targets for diagnosis, prevention and treatment. A strong background in anaerobic microbiology, molecular biology and animal models of infectious disease pathogenesis is required. Knowledge of protein-protein interactions and cell signaling pathways is preferred.
Cryptogenic S. pyogenes Infections: Roles of Antecedent Injury and NSAID Use. Half of patients with life-threatening necrotizing S. pyogenes soft tissue infection lack a defined portal of bacterial entry but often report antecedent non-penetrating injury and subsequent NSAID use. Understanding the roles of injury and NSAID use could lead to novel interventions improve outcomes in this devastating infection. A strong background in cellular physiology and/or biogenesis is required. Experience in animal models of soft tissue injury and infection is preferred.
The successful candidates will:
- Be part of an innovative, cutting-edge and world-renown infectious diseases research group
- Work with Early-stage Principal Investigators and established Senior Investigators and collaborators
- Transition from post-doctoral fellow to Early-stage Investigator
- Mentor undergraduate students
Salary: Incumbents will be employees of the Idaho Veterans Research and Education Foundation and will be offered a competitive salary (DOE) following NIH guidelines of $45 – 55,000 per year. Benefits will be negotiated.
Equal Opportunity Employer: IVREF is an EEO institution and maintains a drug-free workplace. We encourage applications from men and women of all ethnicities and religions, and members of underrepresented groups. All candidates must successfully complete a Federal criminal background check, and provide proof of their current eligibility to work in the USA.