January 3, 2017

 

The Idaho Veterans Research & Education Foundation (IVREF), a nonprofit entity affiliated with the VA Medical Center in Boise, Idaho, announces Post-doctoral Research positions for an NIH funded Center of Excellence in Emerging & Reemerging Infectious Diseases. Candidates will have a recent PhD (<5 years) in microbiology, immunology, cell biology, or related discipline and 0-2 years of post-doctoral experience.  Excellent English communication skills and evidence of scientific accomplishments are required. Ongoing projects include:

Molecular and Cellular Mechanisms of Naturally-acquired Immunity to Streptococcus pyogenes exotoxins. Exotoxins mediate necrotizing S. pyogenes infections and antibiotics that prevent toxin production provide superior protection.  Given rising antibiotic resistance, we seek novel immune-based therapeutics for these life-threatening infections.  A strong background and prior experience in molecular and cellular biology techniques including multi-color flow cytometry/cell sorting, RNA isolation/cloning and animal models of infection is required.  Expertise in display methods (phage, yeast, mRNA, etc), B-cell immunology and immortalization and host/pathogen interactions is preferred.

Mechanisms of Antibiotic-induced Toxin Production in Methicillin-resistant Staphylococcus aureus (MRSA).  We have shown that some antibiotics increase exotoxin protein production in S. aureus, thereby potentially exacerbating clinical disease.  We seek to define regulatory/signaling pathways involved to identify novel therapeutic targets to improve treatment of severe MRSA infection.  A strong background in molecular biology, microbial physiology and/or microbial genetics is required.  Experience in next-gen transcriptome sequencing and animal models of infection is preferred.

Mechanisms of the Leukemoid Reaction (LR) in Life-threatening Clostridial infections.  LR development is a significant predictor of fatal outcome in these infections; however, the underlying mechanisms and the role of the LR in pathogenesis are not understood.  Investigations may reveal novel targets for diagnosis, prevention and treatment.  A strong background in anaerobic microbiology, molecular biology and animal models of infectious disease pathogenesis is required.  Knowledge of protein-protein interactions and cell signaling pathways is preferred.

Cryptogenic S. pyogenes Infections:  Roles of Antecedent Injury and NSAID Use.  Half of patients with life-threatening necrotizing S. pyogenes soft tissue infection lack a defined portal of bacterial entry but often report antecedent non-penetrating injury and subsequent NSAID use.  Understanding the roles of injury and NSAID use could lead to novel interventions improve outcomes in this devastating infection.  A strong background in cellular physiology and/or biogenesis is required.  Experience in animal models of soft tissue injury and infection is preferred.

The successful candidates will:

  • Be part of an innovative, cutting-edge and world-renown infectious diseases research group
  • Work with Early-stage Principal Investigators and established Senior Investigators and collaborators
  • Transition from post-doctoral fellow to Early-stage Investigator
  • Mentor undergraduate students

Salary: Incumbents will be employees of the Idaho Veterans Research and Education Foundation and will be offered a competitive salary (DOE) following NIH guidelines of $45 – 55,000 per year. Benefits will be negotiated.

Equal Opportunity Employer: IVREF is an EEO institution and maintains a drug-free workplace. We encourage applications from men and women of all ethnicities and religions, and members of underrepresented groups.  All candidates must successfully complete a Federal criminal background check, and provide proof of their current eligibility to work in the USA.

Interested applicants:  Please submit an application cover letter, full curriculum vitae, no more than three relevant publications and current contact information for three professional references to: Amy Bryant, Ph.D. at This email address is being protected from spambots. You need JavaScript enabled to view it.. Application review will begin immediately and continue until the positions are filled. More information can be found at www.ivref.org.

IVREF